We added rituximab, reduced /rescheduled cyclophosphamide and methotrexate, capped vincristine, and used combination intrathecal chemotherapy. We and our partners process personal data such as IP Address, Unique ID, browsing data for: Use precise geolocation data | Actively scan device characteristics for identification.. A total of 551 postmenopausal women with breast cancer... For patients with limited prognosis, some medication risks may outweigh the benefits, particularly when benefits take years to accrue; statins are one example. Iscriviti a Facebook per connetterti con Nina Wagner e altre persone che potresti conoscere. Lisocabtagene maraleucel (liso-cel) for treatment of second-line (2L) transplant noneligible (TNE) relapsed/refractory (R/R) aggressive large B-cell non-Hodgkin lymphoma (NHL): Updated results from the PILOT study. The outcomes and ideal management of patients that experience ibrutinib failure are unclear. AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma, 5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial: Letrozole-Associated Bone Loss Prevention, Patient-reported outcomes data from a phase 2 study of idelalisib in patients with refractory indolent B-cell non-hodgkin lymphoma (iNHL), Safety and Benefit of Discontinuing Statin Therapy in the Setting of Advanced, Life-Limiting Illness: A Randomized Clinical Trial. Only verified researchers can join ResearchGate and send messages to other members. Background Vezi profilurile persoanelor care poartă numele de Nina Wagner. Update on a phase I study of the selective PI3Kδ inhibitor idelalisib (GS-1101) in combination with rituximab and/or bendamustine in patients with relapsed or refractory CLL. In total, 241 patients who were newly diagnosed with cHL between January 2000 and December... Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a variety of chemotherapeutic agents. Main navigation. Background: PI3K-delta signaling is critical for proliferation, survival, homing and tissue retention of malignant B cells. We previously presented evidence from a single institution study that rearranged immunoglobulin (Ig) DNA could frequently be detected by clone specific PCR in HIV patients (pts) with lymphoma (Blood 2011;117:4860-2). A systematic literature search identified relevant, randomized controlled trials (RCTs) for the treatment of CIPN. Stem cell transplantation (SCT) provides a second chance at cure, but the prognosis for patients who are not candidates for SCT or who have refractory disease is... Background: SLL, a subtype of indolent non-Hodgkin's Lymphoma (iNHL), is considered the tissue equivalent of chronic lymphocytic leukemia (CLL); each disease is considered a clinical variation of the same biological entity. Iscriviti a Facebook per connetterti con Nina Wagner e altre persone che potresti conoscere. 127 Hedge RdAikenSC 29801phone: 803.649.2766mysaddle.cominfo@mysaddle.com, Niederoesterreich, Oberoesterreich, Wien, Burgenland, Steiermark, Kaernten, Salzburg, Tirol. Secondary outcomes i... Introduction: Rituximab-alkylator combinations are the standard therapies for patients (pts) with iNHL, however, refractory disease nearly uniformly develops. Home / Find a fitter / Nina Wagner. About. Idelalisib (GS-1101) is a first-in-class, selective, oral inhibitor of PI3Kδ that reduces proliferation, enhances apoptosis... 8500 John Cino and Nina Ezrati Wagner Production Join Facebook to connect with Nina Wagner and others you may know. Patient-reported outcomes data from a phase 2 study of idelalisib in patients with refractory indolent B-cell non-Hodgkin lymphoma (iNHL). The purpose of this randomized, placebo-controlled, double-blinded pilot study was to obtain additional data to support conducting a phase III trial to test the use of venlafaxine to prevent oxaliplatin neurotoxicity. Introduction Methods and Patients Explore Nina Woolley Wagner's 170 photos on Flickr! Nina Wagner. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that has shown considerable monotherapy activity in pts with heavily pretreated CLL. View the profiles of people named Nina Wagner. Nina Wagner Der AVEDA Salon NI`NA steht für Höchste Qualität, Sinn für stilvolle Schnitte, zeitlose Klassiker, Offenheit und Trendbewusstsein. Background: Signals through PI3K-delta regulate activation, proliferation and survival of B cells, critically influence homing and retention of B cells in lymphoid tissues, and are hyperactive in many BEcell malignancies. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that has shown monotherapy activity in recurrent MCL (Kahl, ICML 20... 7017 The reported incidence of renal toxicity in osteosarcoma patients is 1.8%, but the incidence in hematologic malignancies is not well characterized. Ich betreue Österreichweit Profis wie auch Freizeitreiter die absolut überzeugt sind von Custom Sätteln. Some partners do not ask for your consent to process your data, instead, they rely on their legitimate business interest. Fifty patients, sched... We assessed the incidence, prognostic features, and outcomes associated with transformation of follicular lymphoma (FL) among 2652 evaluable patients prospectively enrolled in the National LymphoCare Study. Nina Wagner. 'Mild und Leise' (Liebestod) - Tristan und IsoldeNina StemmeDaniel Harding?Truly magnificent singing.Previously uploaded by jiminy22221. Clinical course of patients with cisplatin (CDDP)-associated neuropathy compared to other neurotoxic chemotherapy. Prognostic value of interim FDG-PET in diffuse large cell lymphoma: results from the CALGB 50303 Clinical Trial, Tisagenlecleucel cellular kinetics, dose, and immunogenicity in relation to clinical factors in relapsed/refractory DLBCL, Poor outcomes for double-hit lymphoma patients treated with curative-intent second-line immunochemotherapy following failure of intensive front-line immunochemotherapy, Correlative Analyses of Patient and Clinical Characteristics Associated with Efficacy in Tisagenlecleucel-Treated Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients in the Juliet Trial, Correlation of Bridging and Lymphodepleting Chemotherapy with Clinical Outcomes in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated with Tisagenlecleucel, Safety and Anti-Tumor Activity Study of Loncastuximab Tesirine and Ibrutinib in Diffuse Large B-Cell or Mantle Cell Lymphoma, Allogenic Stem Cell Transplantation for Secondary CNS Lymphoma: A Retrospective Review of 21 Patients, Long-Term Follow-up of Idelalisib Monotherapy in Patients with Double-Refractory Marginal Zone Lymphoma or Lymphoplasmacytic Lymphoma/ Waldenstrom's Macroglobulinemia, Impact of Idelalisib Treatment Interruption with or without Dose Reduction on Outcomes in Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia, A Phase IB Study of Blinatumomab (blina) in Patients with B Cell Acute Lymphoblastic Leukemia (ALL) and B-Cell Non-Hodgkin Lymphoma (NHL) As Post-Allogeneic Blood or Marrow Transplant (allo-BMT) Remission Maintenance, Impact of Tisagenlecleucel Chimeric Antigen Receptor (CAR)-T Cell Therapy Product Attributes on Clinical Outcomes in Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL), Survival Outcomes Following Idelalisib Interruption in the Treatment of Relapsed or Refractory Indolent Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia, Outcomes in patients with aggressive B‐cell non‐Hodgkin lymphoma after intensive frontline treatment failure. While anthracycline-based treatment can cure diffuse large B-cell lymphoma, most patients over age 80 do not receive doxorubicin due to toxicity concerns. Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma, Chemo-Immunotherapy Combination Of Idelalisib With Bendamustine/Rituximab Or Chlorambucil/Rituximab In Patients With Relapsed/Refractory CLL Demonstrates Efficacy and Tolerability, Mature Response Data From a Phase 2 Study Of PI3K-Delta Inhibitor Idelalisib In Patients With Double (Rituximab and Alkylating Agent)-Refractory Indolent B-Cell Non-Hodgkin Lymphoma (iNHL), Idelalisib, a Selective Inhibitor Of PI3Kδ, In Combination With Bendamustine, Fludarabine Or Chlorambucil In Patients With Relapsed Or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL), High Incidence of Methotrexate Associated Renal Toxicity in Patients with Lymphoma: A Retrospective Analysis. Dose-adjusted EPOCH-R compared with R-CHOP as frontline therapy for diffuse large B-cell lymphoma: Clinical outcomes of the Phase III intergroup trial alliance/CALGB 50303, DYNAMO: A Phase II Study of Duvelisib (IPI-145) in Patients With Refractory Indolent Non-Hodgkin Lymphoma, Outcome of Patients with Aggressive B Cell Lymphomas Who Receive Second-Line Salvage Immunochemotherapy Following Treatment Failure of Intensive First-Line Immunochemotherapy, Checkpoint Blockade Therapy May Sensitize Aggressive and Indolent Non-Hodgkin Lymphoma to Subsequent Therapy, Impact of Rituximab Infusion Reactions on Clinical Outcomes in Patients with Diffuse Large B-Cell Lymphoma, Sustained Disease Control for Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma: An Updated Analysis of Juliet, a Global Pivotal Phase 2 Trial of Tisagenlecleucel, Prognostic and Immune-Related Factors for Response to Duvelisib in the Phase 2 DYNAMOTM Clinical Trial in iNHL, Survival Outcomes Following Idelalisib Interruption in the Treatment of Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia, Checkpoint Blockade Therapy May Sensitize Hodgkin Lymphoma to Subsequent Therapy, Immune checkpoint inhibitors as a bridge to allogeneic transplantation with posttransplant cyclophosphamide, Abstract CT110: Clinical pharmacology of tisagenlecleucel (CTL019) in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL), Minimal activity of nanoparticle albumin-bound (nab) paclitaxel in relapsed or refractory lymphomas: results of a phase-I study, High frequency of identical clonal immunoglobulin DNA in pre-treatment tumor and plasma from untreated patients with HIV-associated lymphoma: prospective multicenter trial of the AIDS malignancies consortium (AMC 064), A Phase I/II Trial of Panobinostat in Combination With Lenalidomide in Patients With Relapsed or Refractory Hodgkin Lymphoma, Efficacy and safety of idelalisib in combination with ofatumumab for previously treated chronic lymphocytic leukaemia: an open-label, randomised phase 3 trial, Efficacy and safety of idelalisib in patients with relapsed, rituximab- and alkylating agent-refractory follicular lymphoma: A subgroup analysis of a phase 2 study, Combinations of idelalisib with rituximab and/or bendamustine in patients with recurrent indolent non-Hodgkin lymphoma, Dynamo: A Phase 2 Study Demonstrating the Clinical Activity of Duvelisib in Patients with Relapsed Refractory Indolent Non-Hodgkin Lymphoma, Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505). Nina WAGNER, Upstream Process Development | Cited by 92 | of Lonza Bioscience, Basel | Read 10 publications | Contact Nina WAGNER Informazioni sul coronavirus: Riportiamo la vostra attenzione sul divieto di visita e sull’obbligo di indossare la mascherina dai partire a 6 anni in ogni area della clinica. © 2008-2021 ResearchGate GmbH. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ. We performed a retrospective cohort study of all patients with MCL that experienced disease progression while receiving ibrutinib... Background: Join Facebook to connect with Nina Wagner and others you may know. Tolerability and activity of combinations of the PI3Kδ inhibitor idelalisib (GS-1101) with rituximab and/or bendamustine in patients with previously treated, indolent non-Hodgkin lymphoma (iNHL): Updated results from a phase I study. 2010; 21:851-854). At a median follow-up of 6.8 years, 379/2652 (14.3%) patients transformed following the initial FL diagnosis, including 147 pathologically conf... Aurora A kinase (AAK) is upregulated in highly proliferative lymphomas, suggesting its potential as a therapeutic target. confronto: Nina Stojanovic vs. Stephanie Wagner 10.07.2019 - W60 Versmold Lenalidomide (Revlimid®) is an approved anti-neoplastic therapy for multiple myeloma and myelodysplastic syndrome with del(5q). Phase 1 open-label dose escalation study of the dual SYK/JAK inhibitor cerdulatinib (PRT062070) in patients with relapsed/refractory B-cell malignancies: Safety profile and clinical activity. This report described the 5-year follow-up results. PI3Kδ signaling is hyperactive in many B-cell malignancies. Brentuximab vedotin (BV) is an anti-CD30 monoclonal antibody-drug conjugate that was approved in 2011 for the treatment of patients with anaplastic large cell and Hodgkin lymphomas. Preliminary results of PI3Kδ inhibitor idelalisib (GS-1101) treatment in combination with everolimus, bortezomib, or bendamustine/rituximab in patients with previously treated mantle cell lymphoma (MCL). PI3Kdelta drives proliferation and survival in malignant B-cells. Toxicity of dose-intensive regimens used for Burkitt lymphoma (BL) prompted modification of the CODOX-M/IVAC regimen for HIV+ patients. A phase 1 dose-escalation study of the oral selective inhibitor of nuclear export (SINE) KPT-330 (selinexor) in patients (pts) with relapsed/refractory acute myeloid leukemia (AML). Sehen Sie sich das Profil von Nina Wagner im größten Business-Netzwerk der Welt an. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that has shown considerable monotherapy activity in recurrent iNHL (Kahl, ICML 2011), as well as combination therapy (Fowler, ASCO... 8526 Updated results of a phase III randomized, controlled study of idelalisib in combination with ofatumumab for previously treated chronic lymphocytic leukemia (CLL). Initial response rate of 42% was previously reported in... 8501 Primary outcome was safety and dose-limiting toxicity (DLT). Results of a phase III randomized, controlled study evaluating the efficacy and safety of idelalisib (IDELA) in combination with ofatumumab (OFA) for previously treated chronic lymphocytic leukemia (CLL). PI3K-delta (δ) is critical for activation, proliferation and survival of B cells and plays a role in homing and retention in lymphoid tissues. Final results of a phase I study of idelalisib (GSE1101) a selective inhibitor of PI3Kδ, in patients with relapsed or refractory CLL. In an attempt to alleviate this problem, clinicians and patien... To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors. Alisertib is a novel oral AAK inhibitor without adverse safety signals in early-phase studies that demonstrated preliminary activity in T-cell lymphoma. Patients had a median (range) age of 64 (32-91) years, 34 (53%) had bulky disease (≥1 lymph nodes ≥5 cm), and 37 (58%) had refractory disease. Post-transplant lymphoproliferative disorder (PTLD) after solid organ transplant (SOT): A multicenter real world analysis (RWA) of 877 patients (pts) treated in the modern era. Iscriviti a Facebook per connetterti con Nina Wagner e altre persone che potresti conoscere. See what Nina Wagner (NinWagna) has discovered on Pinterest, the world's biggest collection of ideas. Previous pilot data suggested that venlafaxine could prevent acute and chronic oxaliplatin-related neuropathy. IPAD PRO - DATEN VERSION: IOS 11.4.1 MODELLNAME (12.9 Zoll) APPLE ID: hermann.sen.rhammer@icloud.com PASSWORT: Rheinpfalz33 WLAN PASSWORT: qeqe86we WLAN PASSWORT - in „Einst.“: ejg5bf3mockta IPAD AIR - DATEN (iPad von Anni) VERSION: 12.4.9 APPLE ID: anni.rhammer@icloud.com PASSWORT: Rheinpfalz33 WLAN PASSWORT: qeqe86we WLAN … The product label indicates that 3 patients who were treated with BV developed progressive multifocal leukoencephalopathy (PML), a frequently fatal JC virus-... BACKGROUND Secondary outcomes were pharmacokinetic parameters, pharmacodyn... Background Idelalisib (GS-1101) is a first-in-class, selective, oral inhibitor of PI3Kδ. Incidence of large granular lymphocytosis (LGL) in patients with late cytopenias after allogeneic blood or marrow transplantation (AlloBMT). Serving Niederoesterreich, Oberoesterreich, Wien, Burgenland, Steiermark, Kaernten, Salzburg, Tirol. Name Nina Wagner. Alkylating agent-rituximab combinations are a current standard of care for patients with iNHL. Relapsed or refractory (rel/ref) classical Hodgkin lymphoma (cHL) remains a clinical challenge with limited effective treatments after high dose therapy with autologous stem cell transplantation (ASCT). Im Profil von Nina Wagner sind 7 Jobs angegeben. Nina Stemme (born May 11, 1963 in Stockholm) is an opera singer known for her warm, solid spinto soprano voice, with some qualities of a dramatic soprano. Ann Oncol. 8 mg/m(2) intravenously on a 28-d cycle for a planned 4-8 cycles. 35 were here. A phase 2 study of inotuzumab ozogamicin in patients with indolent B-cell non-Hodgkin lymphoma refractory to rituximab alone, rituximab and chemotherapy, or radioimmunotherapy, Post-ibrutinib outcomes in patients with mantle cell lymphoma, A Phase I Trial of Brentuximab Vedotin in Combination with Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma, Idelalisib Monotherapy and Durable Responses in Patients with Relapsed or Refractory Small Lymphocytic Lymphoma (SLL), Idelalisib Monotherapy and Durable Responses in Patients with Relapsed or Refractory Marginal Zone Lymphoma (MZL), Outcomes with R-CEOP for R-CHOP-ineligible patients with diffuse large B-cell lymphoma are highly dependent on cell of origin, Mature Follow-up from a Phase-2 Study of PI3K-Delta Inhibitor Idelalisib in Patients with Double (Rituximab and Alkylating agent)-Refractory Indolent B-Cell Non-Hodgkin Lymphoma (iNHL), Clinical Course of Oxaliplatin-Induced Neuropathy: Results From the Randomized Phase III Trial N08CB (Alliance), MC11C4: a pilot randomized, placebo-controlled, double-blind study of venlafaxine to prevent oxaliplatin-induced neuropathy, Outcomes of transformed follicular lymphoma in the modern era: A report from the National LymphoCare Study (NLCS), Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline, Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase- , as therapy for previously treated indolent non-Hodgkin lymphoma, Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia, A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL), PI3K?? PI3K-delta signaling is critical for proliferation, survival, homing and tissue retention of malignant B cells. Pharmacokinetics and pharmacodynamics of the dual syk/jak inhibitor PRT062070 (cerdulatinib) in patients with advanced B-cell malignancies. PI3Kδ signaling is hyperactive in many B-cell malignancies. Ich betreue Österreichweit Profis wie auch Freizeitreiter die … Background: PI3K-delta signaling is critical for activation, proliferation and survival of B cells, plays a role in homing and retention in lymphoid tissues, and is hyperactive in many B-cell malignancies. Hospices Civils de Lyon (Centre Hospitalier Universitaire de Lyon), University of Texas MD Anderson Cancer Center, Centre Hospitalier Universitaire de Clermont-Ferrand, Outcomes of patients with up to 6 years of follow-up from a phase 2 study of idelalisib for relapsed indolent lymphomas, Retrospective Analysis of the Impact of Adverse Event–Triggered Idelalisib Interruption and Dose Reduction on Clinical Outcomes in Patients With Relapsed/Refractory B-Cell Malignancies, Allogeneic Transplantation for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Post-Transplantation Cyclophosphamide: Assessing the Importance of Conditioning Regimen, Donor Choice, and Tyrosine Kinase Inhibitor Use, Outcomes of Patients with Limited-Stage Plasmablastic Lymphoma, Reduced-Intensity Induction with Dasatinib Vs. Hypercvad + 2nd Generation TKIs with MRD-Guided Follow-up Therapy Leads to Comparable Rates of MRD-Negative Remission While Reducing Transfusions and Neutropenia in Ph+ ALL, Assessing Early Supportive Care Needs Among Son or Daughter Haploidentical Transplantation Donors, Shortened-Duration Immunosuppressive Therapy after Nonmyeloablative, Related HLA-Haploidentical or Unrelated Peripheral Blood Grafts and Post-Transplantation Cyclophosphamide.